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In laboratory research environments, 5-Amino-1MQ is frequently evaluated for its effects on NNMT activity, nicotinamide metabolism, cellular NAD+ pathways, methyl donor utilization, and metabolic signaling networks

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Summary Keywords amodiaquine, quinoneimine, cytotoxicity, endoplasmic reticulum stress, human glutathione S -transferases P1 Citation Zhang Y, den Braver-Sewradj SP, den Braver MW, Hiemstra S, Vermeulen NPE, van de Water B, Commandeur JNM and Vos JC (2018) Glutathione S -Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells